Searchable abstracts of presentations at key conferences in endocrinology

ea0065oc1.6 | Metabolism and Obesity | SFEBES2019

Metabolic surgery reduces kidney SGLT2 expression in mice

Akalestou Elina , Noriega Livia Lopez , Chabosseau Pauline , Leclerc Isabelle , Rutter Guy

Background: Both metabolic surgery and sodium glucose co-transporter (SGLT2) inhibitors have been demonstrated to improve insulin sensitivity and glucose clearance, but also increase glucagon secretion and cardiovascular health.Aim: To examine the effect of metabolic surgery (Vertical Sleeve Gastrectomy; VSG) on SGLT2 expression in kidney cortex of lean mice.Methods: In order to assess whether exogenous SGLT2 inhibition has the sam...